Study on the Lipid-Lowering Effect of Water-Soluble Chitosan Nanoparticles and Microspheres In Vitro

Abstract:

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Objective: To prepare water-soluble chitosan(WSC) nanoparticles(WSC-NPs) and microspheres(WSC-MPs) , exam the morphology and particle sizes of them and study their effect on lowering lipids . Methods: WSC-NPs and WSC-MPs were prepared by ionic gelation process and spray-drying methods respectively. The effect of WSC-NPs and WSC-MPs on lowering lipids was evaluated by measuring its binding capacities of lipids in the conditions simulating human gastrointestinal tract in vitro. Also, the morphology and particle sizes of WSC-NPs and WSC-MPs were examined under scanning electron microscopy (SEM) and particle sizer. Resluts: WSC-NPs and WSC-MPs were nearly spherical in shape and the mean particles size varied from 200-400 nm and 3-7 μm respectively; The lipids-binding capacities of WSC-NPs and WSC-MPs were more effective compared with water-soluble chiosan. The lipids-binding capacity were enhenced when the particle size were decreased. Conclusion: WSC-NPs and WSC-MPs will be better fat-lowing food additives to replace water-soluble chitosan.

Info:

Periodical:

Advanced Materials Research (Volumes 217-218)

Edited by:

Zhou Mark

Pages:

306-310

DOI:

10.4028/www.scientific.net/AMR.217-218.306

Citation:

B. Gao et al., "Study on the Lipid-Lowering Effect of Water-Soluble Chitosan Nanoparticles and Microspheres In Vitro", Advanced Materials Research, Vols. 217-218, pp. 306-310, 2011

Online since:

March 2011

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Price:

$35.00

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