Study on the Lipid-Lowering Effect of Water-Soluble Chitosan Nanoparticles and Microspheres In Vitro

Abstract:

Objective: To prepare water-soluble chitosan(WSC) nanoparticles(WSC-NPs) and microspheres(WSC-MPs) , exam the morphology and particle sizes of them and study their effect on lowering lipids . Methods: WSC-NPs and WSC-MPs were prepared by ionic gelation process and spray-drying methods respectively. The effect of WSC-NPs and WSC-MPs on lowering lipids was evaluated by measuring its binding capacities of lipids in the conditions simulating human gastrointestinal tract in vitro. Also, the morphology and particle sizes of WSC-NPs and WSC-MPs were examined under scanning electron microscopy (SEM) and particle sizer. Resluts: WSC-NPs and WSC-MPs were nearly spherical in shape and the mean particles size varied from 200-400 nm and 3-7 μm respectively; The lipids-binding capacities of WSC-NPs and WSC-MPs were more effective compared with water-soluble chiosan. The lipids-binding capacity were enhenced when the particle size were decreased. Conclusion: WSC-NPs and WSC-MPs will be better fat-lowing food additives to replace water-soluble chitosan.

• Periodical: Advanced Materials Research (Volumes 217-218)
• Pages: 306-310
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.217-218.306
• Online since: March 2011
• Authors: Bing Gao, Si Hui Wu, Hong Liang Zhang, Yi Tao, Zheng Quan Su
• Keywords: Lipid, Micro-Sphere, Nanoparticle, Water-Soluble Chitosans

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