Study on the Preparation of Chitosan/PVA Sustained - Release Microspheres
Chitosan has prompted the continuous impetus for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. In this study, PEG-chitosan microspheres loaded with levofloxacin for carrying drugs were prepared by the emulsion cross-linking method. The effect of drug process, the emulsifier, the amount of crosslinking agent, stirring speed, temperature, crosslinking time on the prepare experiment were studied. The effect of the quantity of chitosan and PEG, the mass ratio of chitosan and levofloxacin on the drug loading and release ability were studied in drug release experiments too.
J. X. Yu and Q. S. Shi, "Study on the Preparation of Chitosan/PVA Sustained - Release Microspheres", Advanced Materials Research, Vols. 217-218, pp. 71-74, 2011