This paper studies the parameter effect of side retainers on seismic response of bridges with flexible rubber bearings. The pounding effect between girder and side retainers is analyzed by the nonlinear time-history analysis. The pounding and sliding of bearings are simulated by the nonlinear contact elements. Comparative analysis of seismic performance of bridge with/without retainers is carried out. Furthermore, the seismic performances of ordinary retainers and new retainers are compared. Finally, the effect of side retainer parameters on seismic response of bridge is analyzed. The results indicate that the sliding of elastomeric pad bearing should be considered in seismic design. It is shown that the retainers can effectively restrain the relative displacement between girder and piers, and the new type of retainers can greatly reduce the pounding force. It is also proved that both stiffness and gap of the retainer have significant influences on the pounding force.