Rainfall is one of the main factors that influence the stability of slope. Rainfall infiltration will cause soil saturation changing and further influence pore water pressure and medium permeability coefficient. Based on porous media saturation-unsaturated flow theory, the slope transient seepage field is simulated under the conditions of rainfall infiltration. It is shown that change of pore water pressure in slope soil lag behind relative changes in rainfall conditions. As the rainfall infiltrate, unsaturated zone in top half of slope become diminution, the soil suction and shear strength reduce, so stabilization of soil slope is reduced.