Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release

Abstract:

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Biodegradable polymer multi-layer drug delivery microstructure with micro-chambers has some unique advantages in controlled long-term drug delivery, which can enclose drug in the chambers to realize drug release in a controlled fashion. Therefore, it is necessary to obtain the optimal designs of the micro-chambers and their distributions. In this paper, topology optimization of a three-dimensional biodegradable polymer multi-layer drug delivery microstructure was carried out using the cellular automaton (CA)-based evolutionary structural optimization method. The results show that the optimized controlled release system exhibits a preferable linear drug release profile.

Info:

Periodical:

Advanced Materials Research (Volumes 26-28)

Edited by:

Young Won Chang, Nack J. Kim and Chong Soo Lee

Pages:

757-760

DOI:

10.4028/www.scientific.net/AMR.26-28.757

Citation:

R. X. Yu et al., "Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release", Advanced Materials Research, Vols. 26-28, pp. 757-760, 2007

Online since:

October 2007

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Price:

$35.00

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