Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release
Biodegradable polymer multi-layer drug delivery microstructure with micro-chambers has some unique advantages in controlled long-term drug delivery, which can enclose drug in the chambers to realize drug release in a controlled fashion. Therefore, it is necessary to obtain the optimal designs of the micro-chambers and their distributions. In this paper, topology optimization of a three-dimensional biodegradable polymer multi-layer drug delivery microstructure was carried out using the cellular automaton (CA)-based evolutionary structural optimization method. The results show that the optimized controlled release system exhibits a preferable linear drug release profile.
Young Won Chang, Nack J. Kim and Chong Soo Lee
R. X. Yu et al., "Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release", Advanced Materials Research, Vols. 26-28, pp. 757-760, 2007