Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release

Rui Xia Yu; Hua Ling Chen; Xiang Yang Zhou

doi:10.4028/www.scientific.net/AMR.26-28.757

Paper Titles

Synthesis of Zr-Based Glassy Alloy Foams
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Magnetic and Mechanical Properties of Fe-Co-B-Si-Nb-M (M = Al, V, Mo,) Bulk Metallic Glasses
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Fine Crystalline Phase Dispersion in Zr-Based Bulk Metallic Glass by Laser Irradiation
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High-Field Maxwell Stress Effect of Dielectric Actuator Based on Segmented Polyurethane
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Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release
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Evaluation of BAp Orientation Using Mouse Models for Osteoporosis (OPG-KO) and Osteopetrosis (op/op)
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Biofunctionalization of Metal Surface by Immobilization of Poly(Ethylene Glycol) Terminated Amine
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Microstructure and Mechanical Properties of Hot-Pressed Co-Cr-Mo Alloy Compacts
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Effect of Co-Doping Cation on Phase Stability of Zirconia Bioceramics in Hot Water
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 26-28Topology Optimization of Three-Dimensional...

Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-Layer Microstructure for Implantable Drug Controlled Release

Abstract:

Biodegradable polymer multi-layer drug delivery microstructure with micro-chambers has some unique advantages in controlled long-term drug delivery, which can enclose drug in the chambers to realize drug release in a controlled fashion. Therefore, it is necessary to obtain the optimal designs of the micro-chambers and their distributions. In this paper, topology optimization of a three-dimensional biodegradable polymer multi-layer drug delivery microstructure was carried out using the cellular automaton (CA)-based evolutionary structural optimization method. The results show that the optimized controlled release system exhibits a preferable linear drug release profile.