Preparation, Characterization and Antibacterial Activity of Chitosan Schiffbases

Abstract:

Two Schiff bases of chitosan (CTS) were synthesized from 4-methoxylbenzylaldehyde (CH₃O-CTS) and 4-methylbenzylaldehyde(CH₃-CTS). The Schiff bases were characterized by FTIR, DSC-TGA, solid ¹³C CP-Mas NMR, and elemental analysis. Antibacterial activities of the Schiff bases against Escherichia coli and Staphylococcus aureus were measured by the optical density method. The antibacterial activity of the Schiff bases is better than that of the original CTS. The IC₅₀ of CH₃O-CTS and CH₃-CTS against Escherichia coli is respectively 40.3 ppm and 43 ppm, which being 38.5 ppm and 39.5 ppm against Staphylococcus aureus, lower than IC₅₀ of chitosan, being 59.5 ppm and 52 ppm against Escherichia coli and Staphylococcus aureus, respectively.

• Periodical: Advanced Materials Research (Volumes 287-290)
• Pages: 1947-1951
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.287-290.1947
• Online since: July 2011
• Authors: Jing Xian Xu, Ye Ting Lin, Qiang Lin, Wen Yuan, Xue Qiong Yin, Yang Cao
• Keywords: Antibacterial Activity, Chitosan (CS), Preparation, Schiff-Base

References

[1] Kang Y., Lee B., Ko J., Kim G., et al. Int. J. Mol. Sci. 2010;11(10): 4140-4148

[2] VandeVord PJ, Matthew HW, DeSilva SP, et al. J Biomed Mater Res. 2002;59(3): 585-90

[3] Ratajska M., Strobin G., Wrona M. W. et al. Fibres Text East Eur. 2003;11(3): 75-79

[4] Campos M, Cordi LV, Dura Nn, Mei L. Macromol. Symp. 2006; 245–246: 515–518

[5] Fabris R, Chow CW, Drikas M. Water Sci Technol. 2010;61(8): 2119-28

[6] Entsar I. Rabea, Mohamed E.-T. B y, Christian V. et al Biomacromolecules. 2003; 6: 1457-1465 .

[7] Chung YC, Chen CY. Biores. Technol. 2007;99: 2806–2814.

[8] Li Zh, Liu XF, Zhuang XP, Guan YL, Yao KD. J Appl Polym. Sci. 2002;84:2049–(2059)

[9] Gu CJ, Sun B, Wu WH, Wang FC, Zhu MF. Macromol. Symp. 2007;254: 160–166

[10] Slavica BI, Sandra S. Konstantinovic, DragisaS.Savic,et al. Med Chem Res.2010;19: 690-697

[11] Wajid R., Musa K B, Bakhtiar M, et al. Chin Sci Bull. 2004;2:119-122

[12] Seema Varghese, M. K. Muraleedharan Nair. In. J Appl. Biol. Pharm. Tech. 2010;2:608-614

[13] Ding CM, Yin PC, Song QP, Li N, Qiao YB. J East China Uni of Sci Techn. (Natural Science Edition). 2005;3: 296-299

[14] Chen XG Park HJ. Carbohydr Polym. 2003;53:355-359

[15] Liu XF, Guan YL, Yang DZi, Li Z, Yao KD. J Appl Polymer Sci. 2001;79:1324–1335

[16] Guo ZY, Chen R, Xing R, Liu S, Yu HH, Wang PB, Li CP, Li PC. Carbohydr Res. 2006;341:351–354

[17] Abreu FR. Campana-filho, SP. Polímeros [online]. 2005; 2:79-83.

[18] L.Heux, J.Brugnerotto, J.Desbrie res, et al. Biomacromolecules. 2000, 1,746-751