The report treats of the low cycle fatigue (LCF) behaviour of GX12CrMoVNbN9-1 (GP91) cast steel after heat treatment (1040°C/12h/oil + 760°C/12h/air + 750°C/8h/furnace). Fatigue tests were carried out at room temperature for five levels of the controlled total strain amplitude εac = 0.25, 0.30, 0.35, 0.50 and 0.60 %. The research performed within the scope of LCF has shown in general that the investigated cast steel was subject to strong cyclic weakening, revealing no stabilization period at the same time. At the final stage of fatigue there was quick weakening of the material which proceeded till its destruction. The growth of amplitude εac resulted in reducing the number of cycles till the destruction stage.