Formulation of Vanillin Cross-Linked Chitosan Nanoparticles and its Characterization

Abstract:

Chitosan nanoparticles were successfully prepared by chemical cross-linking with vanillin. The nanoparticles were spherical in shape with smooth surface, and the average particle size of chitosan nanoparticles was 141 nm. The formulation of chitosan nanoparticles is based on Shiff reaction between aldehyde group of vanillin and amino group of chitosan. Chitosan nanoparticles prepared by crosslinking with vanillin are promising vehicle for the drug delivery of various anticancer drugs in the chemotherapy of cancers.

• Periodical: Advanced Materials Research (Volumes 335-336)
• Pages: 474-477
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.335-336.474
• Online since: September 2011
• Authors: Guang Wang, Pu Wang Li, Zheng Peng, Mao Fang Huang, Ling Xue Kong
• Keywords: Chitosan (CS), Cross-Linker, Nanoparticle, Vanillin

References

[1] Agnihotri, S.A., Mallikarjuna, N.N., Aminabhavi, T.M. J. Control. Release 100 (2004) 5-28.

[2] Gupta, K.C., Ravi Kumar, M.N.V. Biomaterials 21 (2000) 1115-1119.

[3] Haque, H., Mustafa, A.I., Khan M.A., Carbohydrate Research. 68 (2007) 109-1115.

[4] Gupta, K.C., Jabrail, F.H. Carbohydrate Research. 341 (2006) 744-756.

[5] Jameela, S.R., Jayakrishnan, A., Biomaterials 16 (1995) 769-775.

[6] Mi, F.L., Shyu, S.S., Kuan, C.Y. J. Appl. Polym. Sci. 74 (1999) 1868-1879.

[7] Fürst, W., Banerjee, A. The Annals of Thoracic Surgery. 79 (2005) 1522-1528.

[8] Blancl, M.D., Gomez, C., Olmo, R., Int. J. Pharm. 202 (2000) 29-39.

[9] Cestari, A.R. Vieira, E.F.S., Mattos, C.R.S. J. Chem.Thermodynamics.38 (2006) 1092-1099.

[10] Peng, H.L. Xiong, H.,Li, J.H. Xie, M.Y. Liu, Y.Z. Bai, C.Q. Chen, L.X. Food Chemistry. 211 (2010) 23-28.