Preparation of Sea Buckthorn Oil-Plga Microspheres via the Emulsion-Solvent Evaporation Process Coupling Ultrasonic Treatment

Chong Da Li; Lin Li; Guo Qin Liu; Li Juan Han

doi:10.4028/www.scientific.net/AMR.365.292

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 365Preparation of Sea Buckthorn Oil-Plga Microspheres...

Preparation of Sea Buckthorn Oil-Plga Microspheres via the Emulsion-Solvent Evaporation Process Coupling Ultrasonic Treatment

Abstract:

The optimal preparation conditions of sea buckthorn oil-poly (lactic-co-glycolic acid) (PLGA) microspheres were studied via the emulsion-solvent evaporation process coupling ultrasonic treatment, using polyvinyl alcohol (PVA) as the emulsifier, PLGA as the wall material, a mixture of dichloromethane and ethyl acetate as the oil phase. The research discussed the effects of the PVA concentration, the PLGA dosage, ultrasonic power and ultrasonic time on comprehensive quality index (S) of sea buckthorn oil-PLGA microspheres. The orthogonal experimental design L₉ (3⁴) with the factor analysis was applied to optimize preparation conditions. The experimental date showed that the optimal technology preparation conditions for sea buckthorn oil-PLGA microspheres were as follows: the concentration of PVA 0.125 g/ml, PLGA loading 125 mg, ultrasonic time 10 min, and ultrasonic power 180W. It resulted in sea buckthorn oil-PLGA microspheres that were in more regular and smaller shape, and with a better comprehensive quality index.

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Periodical:

Advanced Materials Research (Volume 365)

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292-298

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.365.292

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Online since:

October 2011

Authors:

Chong Da Li, Lin Li, Guo Qin Liu, Li Juan Han

Keywords:

Micro-Sphere, Microspheres Compositive Quality Indicator, PLGA, Sea Buckthorn Oil

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