Rock fragmentation processes induced by two cutters were simulated by ABAQUS software with different cutter spacing. A series of numerical experiments reproduce the progressive process of rock fragmentation in indentation. The influence of different cutter spacing on the penetration process can also be clearly researched. Rock fragmentation process induced by two TBM disc cutters was performed using the finite element method. The simulation not only provided a realistic description of the rock fragmentation mechanism, but also supported the sufficient proof for the cutter spacing optimization between adjacent disc cutters for a given penetration depth. When the penetration is 6 mm, the cutter spacing optimization is 48 mm. The result shows that the numerical simulations will contribute to an improved knowledge of rock fragmentation in indentation and will be useful for performance assessment of TBM, which will enhance the efficiency of rock breaking.