Synthesis and Characteristics of Interpenetrating Polymer Network Hydrogels Based on Konjac Glucomannan with Different Molecular Weights and Poly(acrylic acid)

Abstract:

Konjac glucomannan with different molecular weights/poly(acrylic acid) hydrogels were prepared in this paper. The structure of the IPN hydrogels was characterized by FT-IR and SEM. The swelling ratio of these hydrogels showed they had pH-sensitive properties and the enzymatic degradation tests showed the hydrogels retain the enzymatic degradation character of KGM. Furthermore, hydrogel composed of native KGM degraded sharply in enzymatic degradation test and it had bigger swelling ratio and weight loss ratio than those hydrogels which composed of lower molecular weights KGM. Therefore, hydrogels composed of lower molecular weight might release drug more stable when they were used as drug carrier.

• Periodical: Advanced Materials Research (Volumes 393-395)
• Pages: 1004-1007
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.393-395.1004
• Online since: November 2011
• Authors: Xue Yao, Xue Gang Luo, Ben Chao Han
• Keywords: Enzymatic Degradation, Interpenetrating Polymer Network, Konjac Glucomannan, Molecular Weight (MW), Poly(Acrylic Acid)

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