Preparation and Characterization of Heparin-Immobilized Poly(Ether Urethanes)

Li Ming Lian; Bing Leng; Xiao Hua Ma

doi:10.4028/www.scientific.net/AMR.393-395.236

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 393-395Preparation and Characterization of...

Preparation and Characterization of Heparin-Immobilized Poly(Ether Urethanes)

Abstract:

Heparin (Hep)-immobilized poly(ether urethanes) (PU) was prepared by a unique preparation procedure. Firstly, the poly(ether urethanes)(PU) containing diester groups in the side chains were synthesized. Then, PU was dispersed in aqueous solutions and immobilized with heparin after the hydrolysis of diester groups and carboxylation. The Fourier transform infrared spectroscopy (FTIR) and water contact angle (WCA) were used to characterize the heparin-bonded PU. The amount of heparin grafted on the PU was determined to be 0.57wt.% by the toluidine blue method. The heparin-immobilized PU could release just 12% of the immobilized heparin in the early 10 hours of the 70 hours immobilized heparin stability test.

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Periodical:

Advanced Materials Research (Volumes 393-395)

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236-239

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.393-395.236

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Online since:

November 2011

Authors:

Li Ming Lian, Bing Leng, Xiao Hua Ma

Keywords:

Hemocompatible Coating, Heparinization, Poly(Ether Urethanes)

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