Preparation of Controlled-Release Tablets of Sasanquasaponin

Abstract:

he controlled-release tablets of sasanquasaponin (SQS) were prepared by using SQS, hydroxypropyl methyl cellulose, ethylcellulose and lactose as the main drug, skeleton material and fillers, respectively. The effects of the dosage of hydroxypropyl methyl cellulose and ethylcellulose on release rate were studied. The release rate curve of the data of the prescription of the controlled-release tablets of SQS were fitted as zero order, one order and Higuchi equation. The release rate of the controlled-release tablets of SQS were controlled by controlling the dosage of hydroxypropyl methyl cellulose and ethylcellulose. The influence of the dosage of hydroxypropyl methyl cellulose on release rate of the controlled-release tablets of SQS was the biggest factor. The prescription of the controlled-release tablets of SQS contains in each piece: SQS 200mg, hydroxypropyl methyl cellulose 40mg, ethylcellulose 30mg, lactose 30mg. The controlled-release tablets of SQS release SQS by slowness and constant in 12h.

• Periodical: Advanced Materials Research (Volumes 396-398)
• Pages: 1684-1687
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.396-398.1684
• Online since: November 2011
• Authors: Xiao Zhen Liu, Ju Hua Yang, Zhong Fang Lai, Ling Ling Guo, Ling Ling Song, Ya Qin Bi
• Keywords: Controlled-Release, Ethylcellulose, Hydroxypropyl Methyl Cellulose, Release Rate, Sasanquasaponin

References

[1] Z.F. Lai, Y.Z. Chen, J. Chen and X.Z Liu: Chinese Herbal Drug Research Trends, Nova Science Publishers, Inc. 2007, p.147

[2] Z.F. Lai, Z.Q. Shao, Y.Z. Chen, M. He: J. Pharmacol. Sci. Vol. 94 (2004), p.313

[3] A.S. Attele, J.A. Wu, C.S. Yuan: J Biochem. Pharmacol Vol.58 (1999), p.1685

[4] J C.X. Liu, P.G. Xiao: J. Ethnopharmacol Vol.36 (1992), p.27

[5] M.Q. Guo, F.G. Song, Z.Q Liu, et al.: Analytica Chimica Acta Vol. 557 (2006), p.198

[6] P. Sur, T. Chaudhuri, J.R. Vedasiromoni, et al.: Phytotherapy research Vol.15 (2001), p.174

[7] Q.R. Huang, S.Y. Cao, M. He, P. Li and W.J. Peng: Chinese Journal of Clinical harmacology and Therapeutics Vol.8 (2003), p.170

[8] Q.R. Huang, Y.C. Dai, M. He and Y.M. Luo: Chinese Pharmacological Bulletin. Vol.21 (2005), p.1092

[9] Q.R. Huang, M. He, P. Li, W.J. Peng and S.Y. Cao: Chinese Pharmacological Bulletin Vol. 19 (2003), p.1034

[10] Q.R. Huang, M. He, Y.C. Dai and Y.M. Luo: ChineseTraditional and Herbal Drugs Vol.36 (2005), p.1831

[11] X.Y. Hou, X.C. Wan, H.P. Wu: Food Science Vol.27 (2006), p.51

[12] S.H. Hu, W.J. Hu, L.Y. Xu, L.H. Zhang and Q.M. Li: China Oils and Fats Vol. 23 (1998), p.49

[13] X.Z. Liu, Z.F. Lai, J. Chen and Y.Z. Chen: CN200810042745.9, 2008-9-11

[14] Q.R. Huang, M. He, P. Li, W.J. Peng and S.Y. Cao: Chinese Pharmacological Bulletin Vol. 19 (2003), p.1034

[15] State Pharmacopoeia Commission: Chinese Pharmacopoeia, 2005 edition. Beijing: Chemical Industry Press, 2005.

[16] X.Z. Liu, R. Ran: Chinese Journal of Synthetic Chemistry Vol.5 (2008), p.611