Interaction between Hydroxyapatite and Collagen

Abstract:

To study the interaction between hydroxyapatite (HAP) and collagen in bone, we researched the phenomenon of collagen biomineralization and self-assembly in viro by uv-vis spectra and circular dichroism (CD) spectra. The materials prepared by self-assembly collagen and collagen-HAP showed layer structures. And the product prepared by collagen-HAP had better and more compact appearance. The decrease of speed of collagen self-assembly was caused by calcium ion or strontium ion added. The trough of CD spectra moved down in calcium-containing solution and moved up when forming precipitation of calcium phosphate from the solution. It indicated that the effect of collagen self-assembly was caused by calcium ions, strontium ions etc. in the solution. The IR spectrum proved that a coordinate bond formed between calcium ion and amide groups on collagen.

• Periodical: Advanced Materials Research (Volume 412)
• Pages: 384-387
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.412.384
• Online since: November 2011
• Authors: Zhao Long Huang, Gui Yang Liu, Ying He, Zhong Zhou Yi, Jun Ming Guo
• Keywords: Calcium (II) Complexes, Collagen, Coordinate Bond, Molecular Absorption Spectrums

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