Design and Synthesis of PEG Curcumin Monomer for the Comb-Like Polymer Prodrug

Fei Qiu; Lin Wei

doi:10.4028/www.scientific.net/AMR.415-417.1821

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 415-417Design and Synthesis of PEG Curcumin Monomer for...

Design and Synthesis of PEG Curcumin Monomer for the Comb-Like Polymer Prodrug

Abstract:

Curcumin is a kind of compound with various biological activities. However, curcumin suffers from low aqueous solubility, instability and poor bioavailability in vivo, which restrained it from clinical application. In this paper, novel water soluble curcumin prodrug monomer was synthesized by reacting curcumin with methacryloyl polyethylene glycol (MA-PEG), and succinic anhydride. IR, MS and 1H NMR spectroscopy were carried out to verify the products. We studied and modified the reaction conditions. The drug load rate of the monomer was 26.9%, which was 2-4-fold than previous report, and the solubility of it could be increased to 1.17g/L, which was about 150 times higher than previous report. The monomer is used to prepare comb-like polymer prodrugs.

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Periodical:

Advanced Materials Research (Volumes 415-417)

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1821-1824

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.415-417.1821

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Online since:

December 2011

Authors:

Fei Qiu, Lin Wei

Keywords:

Curcumin, Polyethylene Glycol (PEG), Polymer Prodrug, Synthesis

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