Controlled Release of Tablets Containing Poorly Water Soluble Model Drug Coated with Kollicoat MAE 30DP

Abstract:

In this project we have prepared the tablets with a coating of pH-sensitive polymer Kollicoat MAE 30DP. For this purpose the core tablets prepared from poorly water soluble model drug and other excipients were coated by a fluidized bed apparatus at the exhaust air temperature of 30°C and spraying rate of 0.55 g/min. The highest coating time was 384 min which leads to the film thickness of 648 µm. The coated tablets were gastric resistant for one hour and resistant against intestinal fluid pH 6.8 up to 70 min. The coating film has a good quality with smoothness and dense packing. However, if the thickness was high e.g. 600 µm the film surface had more wavy structure. The results served to formulate the colon delivery system.

• Periodical: Advanced Materials Research (Volumes 418-420)
• Pages: 2186-2189
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.418-420.2186
• Online since: December 2011
• Authors: Stefan Lemke, Mont Kumpugdee-Vollrath
• Keywords: Coating, Controlled-Release, Dissolution, Fluidized Bed, Kollicoat, SEM

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