The Synthesis of Comb-Like Polymeric Prodrugs of 5-Fluorouracil Derivatives

Fei Qiu; Hui Yan; Lin Wei; Yong Diao

doi:10.4028/www.scientific.net/AMR.421.35

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 421The Synthesis of Comb-Like Polymeric Prodrugs of...

The Synthesis of Comb-Like Polymeric Prodrugs of 5-Fluorouracil Derivatives

Abstract:

Two comb-like polymeric prodrugs of 5-fluorouracil derivatives (p(MAA-PEG400-5Fu), p(MAA-PEG2000-5Fu)) were synthesized from monomers, methacryloyl (polyethylene glycol 5-fluorouracil acetyl) (MAA-PEG-5Fu) through radical polymerization using azobisisobutyronitrile (AIBN) as initiator in N,N-dimethyl formamide solution, which structures were confirmed by means of IR, 1HNMR, UV-Vis, MS and GPC spectroscopy. The drug loading rates of the two prodrugs (p(MAA-PEG400-5Fu), p(MAA-PEG2000-5Fu)) were 25.51%, 10%, respectively.

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Periodical:

Advanced Materials Research (Volume 421)

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35-38

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.421.35

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Online since:

December 2011

Authors:

Fei Qiu, Hui Yan, Lin Wei, Yong Diao

Keywords:

5-Fluorouracil, Comb-Like Polymeric Prodrug, Polyethylene Glycol (PEG), Synthesis

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