Process Research of 1-(3,4-Dichloropheny)-3-Methyl-Pyrazolone-5-one Synthesis

Abstract:

The new process of 1-(3,4-dichloropheny)-3-methyl-pyrazolone-5-one (34DCPMP) synthesis had been discovered, which using 3,4-dichloro phenylhydrazine hydrochloride(DCPH) and ethyl acetoacetate as the raw material , The product was obtained by the route during cyclization in aqueous medium. The structure of products was confirmed by 1HNMR, 13CNMR and IR. The effects of factors on the yield of products were investigated. It was found that the yield of 34DCPMP can reach 98.7% under the optimal reaction condition of n(34DCPH):n(ethyl acetoacetate) with 1:1.1, n(34DCPH):n(Na2SO3) with 1.3:1 at 80°C, and pH 7.5 for 3h. The chromatographic purity can be higher than 98.2%.

• Periodical: Advanced Materials Research (Volumes 450-451)
• Pages: 223-227
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.450-451.223
• Online since: January 2012
• Authors: Hui Qun Yu, You Bin Mo, Yan Fang Liao, Hai Zhou, Zhi Peng He
• Keywords: 1-(3, 4-Dichloropheny)-3-Methyl-Pyrazolone-5-One, Aqueous Medium, Ethyl Acetoacetate, Fine Chemical Intermediates

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