Preparation of Nanoparticles by Crosslinking Folate Conjugated Chitosan with Vanillin and its Characterization

Min Zhou; Pu Wang Li; Guang Wang; Zi Ming Yang; Zheng Peng; Ling Xue Kong

doi:10.4028/www.scientific.net/AMR.466-467.454

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 466-467Preparation of Nanoparticles by Crosslinking...

Preparation of Nanoparticles by Crosslinking Folate Conjugated Chitosan with Vanillin and its Characterization

Abstract:

Functionalized chitosan (CS) were widely used as drug delivery system in the chemotherapy of various disease. In this work, folate (FA) was conjugated into chitosan molecular as targeting ligand based on Schiff reaction between –NH₂ group of CS and –COOH group of FA. And nanoparticles were made by emulsion method with vanillin novel cross-linking agent. The FA modified CS and its nanoparticles were characterized by Fourier transform spectroscopy (FT-IR), scanning electron microscope (SEM) and Zeta potential. SEM results confirmed the nanoparticles made from FA-CS conjugate were spherical in shape and were about 100 nm in size. Zeta potential analysis revealed that the nanoparticles were negatively charged with charge density of -7.73mV.

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Periodical:

Advanced Materials Research (Volumes 466-467)

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454-457

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.466-467.454

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Online since:

February 2012

Authors:

Min Zhou, Pu Wang Li, Guang Wang, Zi Ming Yang, Zheng Peng, Ling Xue Kong

Keywords:

Chemical Modification, Chitosan, Folic Acid, Vanillin

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