A Practical Synthetic Method for 7-ATCA

Abstract:

7-ATCA is a major intermediate of Cefditoren pivoxil. Literatures reported 7-ATCA was generally synthesized by the method of sheer chemistry or combinative method of biochemistry and chemistry. Considering reduction of environmental pollution, the combinative method has more preference. We optimized the amount of sodium iodide and 4-methyl-5-thiazolaldehyde in Wittig reaction and the sorts of reagents for removing C-4 deprotection group. 7-ATCA was obtained after penicillin acylase hydrolysis of C-7 protection group in a mild condition. The structure of 7-ATCA was characterized by ¹H NMR and the total yield was up to 55%.

• Periodical: Advanced Materials Research (Volumes 479-481)
• Pages: 982-985
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.479-481.982
• Online since: February 2012
• Authors: Chun Hui Gao, Yue Zhang, Wei Li, Cheng Guo Jia
• Keywords: 4-Methyl-5-Thiazolaldehyde, GCLE, PGA, Trichloroacetic Acid

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