Estrogenicity of Six Typical Aqueous Pollutants

Abstract:

This paper studied the estrogenicity of six typical aqueous EDCs by examining their proliferation of MCF-7. These six EDCs were 17-β Estradio (E2), biphenol A (BPA), nonyl phenol (NP), di-n-butyl phthalate (DBP), hexachlorobenzene (HCB) and Cadmium (Cd). Results showed that MCF-7 proliferation was sensitive to these compounds. E2 was the most sensitive one and the effective concentration was 10^-14 mol/L, while Cd was the least sensitive one and the effective concentration was 10^-8 mol/L. The sensitivity of these six EDCs ranked as: E2 > BPA ≥ NP > DBP ≥ HCB > Cd. On the other hand, the cell proliferation extent of these compounds ranked as: HCB > DBP > BPA > Cd > NP ≥ E2. Very complex dose-time-response curves were observed for all six EDCs, indicating that many factors impacted the cell grow.

• Periodical: Advanced Materials Research (Volume 499)
• Pages: 455-458
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.499.455
• Online since: April 2012
• Authors: Guang Ming Zhang, Lang Lang
• Keywords: BPA, Cd, DBP, E2, Estrogenicity, HCB, NP

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