Design and Preparation of Synthetic Hydrogels by Redox Initiation via Free Radical Polymerisation for Biomedical Use as Wound Dressings

Abstract:

Design and preparation of synthetic hydrogels for biomedical use as wound dressings were studied. A partially hydrated hydrogel of sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was prepared by redox initiation via free radical polymerisation in aqueous solution. In this reaction, of 40% w/v Na-AMPS aqueous solution was prepared, with 1.0% by mole of monomer ethylene glycol dimethacrylate (EGDM) as crosslinker, and potassium persulfate (K₂S₂O₈) as the free radical initiator at a concentration of 0.5% mol monomer with potassium metabisulfite (K₂S₂O₅) and ferrous sulphate (FeSO₄) as coinitiator. The results showed that the hydrogel sheets gave good coherency, transparency, flexibility, high oxygen permeability, good skin adhesion and were non-toxic. The water properties of the hydrogel sheets (absorption, retention, water vapour transmission rate) were balanced which can maintain the moist environment of the wound. It is concluded that Na-AMPS hydrogels have properties which show potential for biomedical use as a wound dressing for second degree burn.

• Periodical: Advanced Materials Research (Volume 506)
• Pages: 315-318
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.506.315
• Online since: April 2012
• Authors: C. Witthayaprapakorn, Robert Molloy
• Keywords: Hydrogel, Redox Initiation, Wound Dressing

References

[1] O. Wichterle, and D. Lim: Nature Vol. 185 (1960), p.117.

[2] K.L. Fith , P.B. Johnsonz: Human Life Science, Rinehart and Winston, (1977).

[3] P.H. Corkhill, C.J. Hamilton, B.J. Tighe: Biomaterials Vol. 10 (1989), p.3.

[4] P.H. Corkhill, A.M. Jolly, C.O. Ng, B.J. Tighe: Polymer Vol. 28 (1987), p.1758.

[5] C.D. Young , J.R. Wu, T.L. Tsou: J. Membrane Sci. Vol. 146(1)(1998), p.83.

[6] S. Durmaz, O. Okay: Polymer Vol. 41 (2000), p.3693.

[7] A.A.A. Abdel-Azim, M.S. Farahat, A.M. Atta, A.A.F. Atef: Polym. Adv. Technol. Vol. 9 (1998), p.282.

[8] A.M. Atta: Polym. Adv. Technol. Vol. 13 (2002), p.567.

[9] Y. Liu, J.J. Xie, X.Y. Zhang: J. Appl. Polym. Sci. Vol. 90 (2003), p.3481.

[10] A Formulators Guide, Ciba Geigy Ltd, Publication 16065 (1995), p.7.

[11] G. Odian: Principles of Polymerization, 4th Edn., Wiley-Interscience, (2004), p.218.

[12] C.O. Ng, B.J. Tighe: Br. Polym. J Vol. 8 (1976), p.118.