Release of Growth Factor from Platelet-Rich Fibrin and its Stability in Sinus Lifting in Minipigs

N. Pattaraporncharoen; P. Pripatnanont; S. Suttapreyasri; N. Leepong

doi:10.4028/www.scientific.net/AMR.506.367

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 506Release of Growth Factor from Platelet-Rich Fibrin...

Release of Growth Factor from Platelet-Rich Fibrin and its Stability in Sinus Lifting in Minipigs

Abstract:

Platelet-rich fibrin (PRF) is platelet concentration that contains growth factors and acts as a biodegradable scaffold. The aims of this study were to determinethe quantity ofentrappedgrowth factors (Platelet derived growth factor BB, PDGF-BB) in the PRF and radiographically assess the stability of the fibrin in maintaining the lifted sinus space in minipigs. From the in vitro study, PRF was found slowly releasing thegrowth factor, PDGF-BB, during the ex-vivo period of 60 minutes, and the amount (1,963.93±380.17 pg/ml) was comparable to the total amount from immediate extraction either by physical (2,492.2±199.78 pg/ml) or chemical lysis (2,227.32±566.59 pg/ml).In vivo study, PRF wasable to be retained in the sinus of minipigs with minimal collapse during the first 2 weeks after application. PRF has been proven to be a source for growth factors and is able to be retained in the body during the initial period of wound healing.

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Periodical:

Advanced Materials Research (Volume 506)

Pages:

367-370

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.506.367

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Online since:

April 2012

Authors:

N. Pattaraporncharoen, P. Pripatnanont, S. Suttapreyasri, N. Leepong

Keywords:

Growth Factor , PDGF-BB, Platelet-Rich Fibrin, Sinus Lift

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