Preparation of Zingiber officinale Extract Loaded Solid Lipid Nanoparticles

N. Ratcharin; Paveena Wongtrakul; Ratana Indranupakorn

doi:10.4028/www.scientific.net/AMR.506.389

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 506Preparation of Zingiber officinale Extract Loaded...

Preparation of Zingiber officinale Extract Loaded Solid Lipid Nanoparticles

Abstract:

Solid lipid nanoparticles (SLNs) loaded ginger extract were prepared by microemulsion technique. The nanoparticles were composed of stearic acid as solid lipids, Cremophor RH 40 as surfactant and ethanol as co-surfactant. It was found that variation in the amount of surfactant and co-surfactant had profound effects on the mean particle size, the drug entrapment efficiency and loading capacity. Transmission electron microscope (TEM) revealed the spherical nature of the particles. The mean particle size of SLNs ranging between 453.1 and 551.7 nm were measured by dynamic light scattering (DLS). The entrapment efficiency (EE) and drug loading capacity (LC) determined by high performance liquid chromatography (HPLC) found to be in the range of 85.2390.07% and 1.411.49%, respectively.

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Periodical:

Advanced Materials Research (Volume 506)

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389-392

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https://doi.org/10.4028/www.scientific.net/AMR.506.389

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Online since:

April 2012

Authors:

N. Ratcharin, Paveena Wongtrakul, Ratana Indranupakorn

Keywords:

Antioxidant, Ginger Extract, Solid Lipid Nanoparticles

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