Cream Stick Containing Natural Oil for Cracked Heel

Article Preview

Abstract:

The cracked heel is one of popular problems occurred within thai society. In this study, stick-formed preparation (ST) was developed for portability and convenient to use. The formula contained natural oil, coconut oil (C) or rice bran oil (R), for moisturizing purpose. It was found that 10% R giving a suitable hardness for ST. After addition of 5% salicylic acid (SA) in ST, its hardness was decrease. The modification of formula was performed to obtain a suitable hardness. The ability of moisture retaining (MR) from ST and commercial cream (CO) were evaluated at 32°C for 24 hr with 50% relative humidity, the result was shown that ST giving better MR than CO (P=0.0028). After 4 cycles of freeze-thaw stability study, the ST hardness was not significantly change (P>0.05). However, the amount of SA in ST from dissolution with Paddle over Disc method using acetate buffer pH 5.5 at 32°C was lower than in CO.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

461-464

Citation:

Online since:

April 2012

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2012 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] D. Rudikoff : Clinics in Dermatology Vol. 16 (1998), pp.99-107.

Google Scholar

[2] M. B. Fenkey, A. Asucion, N. Trookman: J. Am. Acad. Dermatol. Vol. 56 Supplement 2 (2007) p. AB91.

Google Scholar

[3] S. Hornby, N. Trookman: J. Am. Acad. Dermatol. Vol. 56 Supplement 2 (2007) p. AB94.

Google Scholar

[4] M. J. Lawrence and G.D. Rees: Adv. Drug Deliv. Rev. Vol. 45 (2000) pp.89-121.

Google Scholar

[5] B. A. Green, R. J. Yu, E.J. Van Scott: Clinics in Dermatology Vol. 27 (2009), pp.495-501.

Google Scholar

[6] K. Ousey : J. Orthopaedic Nursing Vol. 13 (2009), pp.97-104.

Google Scholar

[7] V. Teeranachaideekul, P. Boonme, E. B. Souto, R.H. Muller, V. Junyaprasert: J. Control. Rel. Vol. 128 (2008) pp.134-141.

Google Scholar

[8] M. Trotta, M. Gallarate, M.E. Carlotti and S. Morel : Int. J. Pharm. Vol. 254(2003) pp.235-242.

Google Scholar

[9] J. J. Cevera, L. L. Bolton, M. D. Kerstein: J. Diabetic and its Complication. Vol. 11 (1997), pp.358-366.

Google Scholar

[10] H. Suzuki, D. Nakai, T. Seita, Y. Sugiyama.: Adv. Drug Deliv. Rev. Vol. 19 (1996) pp.1-32.

Google Scholar