In this paper, a new mathematical model and grinding method of ball-end milling cutter are proposed, based on the orthogonal spiral cutting edge curve. The movements of grinding wheel and ball-end milling cutter are presented while grinding rake face. In order to grind conveniently and avoid interference, a conical wheel is also designed and employed to grind the rake face of ball-end milling cutter on a grinder. In order to improve the machining characteristics of ball-end milling cutter, the model of rake face with equal rake angle is established. The software of ball-end milling cutter is developed to design and optimize different shapes of rake face. Furthermore, the simulation analysis on rake face with equal rake angle is carried out to confirm the validation of the mathematical models.