Preparation of Paclitaxel-Loaded Microspheres with Fe3O4 Nanoparticles and Study of their Target-Orientation and Sustained-Release Property

Sheng Cui; Ben Lan Lin; Xiao Dong Shen

doi:10.4028/www.scientific.net/AMR.535-537.521

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 535-537Preparation of Paclitaxel-Loaded Microspheres with...

Preparation of Paclitaxel-Loaded Microspheres with Fe₃O₄ Nanoparticles and Study of their Target-Orientation and Sustained-Release Property

Abstract:

Paclitaxel-loaded microspheres with magnetic Fe3O4 nanoparticles were synthesized with albumin as carrier. The morphology was characterized by high-resolution transmission electron microscopy (HRTEM). The drug-loading rate and entrapment rate of the microspheres were researched by ultraviolet and visible spectrophotometer. The inhibition action of taxol microspheres to growth of esophagus cancer Eca109 cell were examined by MTT method. The result shows that it is regular spherical. The mean size and size distribution of microspheres are 275.6nm and 144.3nm by Zetasizer3000. The drug-loading rate is 3.013% and the entrapment rate is 35.26%. It has excellent target-orientation and sustained-release property which can prevent the growth of Eca109 cell.

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Periodical:

Advanced Materials Research (Volumes 535-537)

Pages:

521-524

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.535-537.521

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Online since:

June 2012

Authors:

Sheng Cui, Ben Lan Lin, Xiao Dong Shen

Keywords:

Inhibition to the Growth of Cell, Sustained-Release, Target-Orientation Anticancer Drug

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