Synthesis of γ-L-Glutamylalkylamides Catalyzed by Escherichia coli Having γ-Glutamyltranspeptidase Activity

Abstract:

γ-L-glutamyl alkylamines have potential medicinal value. In this research, five different γ-L-glutamyl alkylamines were synthesized. The result showed that substrate specificity of alkylamines, from high to low, is methylamine, ethylamine, n-propylamine, isopropylamine and n-butylamine. The reaction was optimal at pH 9.5 and 45°C, and the optimal substrate mole ratio of L-glutamine to alkylamine was 1:3 (mol/mol).Under these conditions, conversion rate of L-glutamine is about 90% (mol/mol)．

• Periodical: Advanced Materials Research (Volumes 550-553)
• Pages: 1177-1181
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.550-553.1177
• Online since: July 2012
• Authors: Fei Zhang, Yin Liu, Pei Xin He
• Keywords: Enzymatic Synthesis, γ-Glutamyltranspeptidase, γ-L-Glutamylalkylamide

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