Pathology Changes of Kidney in Mouse Following DBP&DEHP Exposure

Abstract:

The toxic effects of di-2-ethylhexyl phthalate（DEHP）and di-n-butyl phthalate（DBP）on the kidney of mouse was studied. Forty mice were randomly divided into 4 groups , 10 mice in each group. There were three experimental groups:DBP+DEHP（2.5g/kgDEHP+0.5g/kgDBP）,DEHP(2.5g/kg）,DBP（0.5g/kg）and a control group which was given coin oil. The experiment was conducted through gavage every other day for 35 days. The organ coefficients were counted and pathological changes in kidney were observed. The weights of mice of each group increased with the time,but there were no difference between each group in statistic. The organ coefficients of kidney of DEHP and DBP&DEHP group were significantly higher than that of DBP group and control group. Infected groups appeared injury to some extend by observing the pathological section. It reveals DBP and DEHP have toxicity on kidney.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 1660-1663
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.1660
• Online since: July 2012
• Authors: Yu Lan Hao, Qing Zhao Li, Guo Ying Zheng
• Keywords: DBP, DEHP, Plasticizer, Toxic Action

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