Depressions of Urinary Crystallites: A Direct Proof of Citric Acid Dissolving Calcium Oxalate Stones in Vivo

Yi Ming Ding; Zhi Yue Xia; Guang Na Zhang; Jian Ming Ouyang

doi:10.4028/www.scientific.net/AMR.554-556.47

Paper Titles

Kinetics of Potassium Dihydrogen Phosphate Single-Crystal Growth Mapped by the Chemical Bond Simulation
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Study on the Effect of Magesium Ion on the Crystal Phase of Calcium Carbonate
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Controllable Fabrication of Layer Structures by Self-Assembled Perylene Derivative
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Mesomorphism of Hexa-Peri-Hexabenzocoronene Discotic Liquid Crystals with Odd-Carbon Alkyl Chains
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Depressions of Urinary Crystallites: A Direct Proof of Citric Acid Dissolving Calcium Oxalate Stones in Vivo
p.47

Preliminary Study of Refined Naphthalene Production with Fractional Crystallization
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Crystal Structure of 3-(5-Acetyl-2-Aminothiazol-4-Ylthio)- 4-Hydroxypentan-2-one
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Synthesis and Properties of Dendrimer Liquid Crystal Based on Ester and Ether of Gallic Acid
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First Principles Investigations on the Supramolecular Structure of 1,5-Diaminotetrazole
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 554-556Depressions of Urinary Crystallites: A Direct...

Depressions of Urinary Crystallites: A Direct Proof of Citric Acid Dissolving Calcium Oxalate Stones in Vivo

Abstract:

Scanning electron microscopy (SEM), X-ray power diffraction (XRD) and Zeta potential () analyzer were used to investigate the changes of morphology, species, crystal quantity, , and aggregation state of urinary crystallites of calcium oxalate (CaO_xa) stone formers before and after taking drug potassium citrate (K₃cit). Before taking K₃cit the edges and corners of urinary crystallite were sharp and aggregated significantly, the main components were uric acid, calcium oxalate monohydrate (COM) and phosphate, etc. While after taking K₃cit for one week, some of urinary crystallites became blunt, the aggregated crystallites and the species of crystallites were obviously reduced, the amount of uric acid was reduced, but the percentage of calcium oxalate dihydrate (COD) and the absolute value of increased. Especially crystal depressions emerged at the surface of some crystallites, which was the direct proof of K₃cit dissolving CaO_xa stones in vivo. From the point of coordination between K₃cit and Ca²⁺, the increase of pH and citric acid concentration excreted in urine after taking K₃cit, the mechanism of how K₃cit inhibit the formation of COM stones was discussed.