Preparation and Characterization of Cyclophosphamide-Loaded Chitosan Microspheres

Abstract:

Chitosan microspheres were prepared by using a cross linking agent combined with an emulsion technique. Cyclophosphamide was loaded as an anticancer agent. Obtained microspheres were spherical and regular, with a smooth surface morphology, having an average diameter of 15.7±9.0μm. After preparation, the drug-loading rate and entrapment rate of cyclophosphamide was investigated by UV spectrophotometry. Drug release was tested in vitro in a dynamic dialysis system with a dialysis bag. The chitosan microspheres prepared were proved to have good drug release profiles.

• Periodical: Advanced Materials Research (Volume 621)
• Pages: 130-133
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.621.130
• Online since: December 2012
• Authors: Yi Lin Ding, Su Su Ding, Guo Fang Ding
• Keywords: Chitosan, Cyclophosphamide, Micro-Sphere, Slowly-Releasing

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