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Synthesis and In Vitro Anti-Breast Cancer Activity of Trametenolic Acid B Derivatives

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Abstract:

Six compounds were synthesized from the lanostane-type tetracyclic triterpenoid of trametenolic acid B with the aim of obtaining more active compounds, which were characterized by NMR, IR, ESI-MS and elemental analysis. Their cytotoxic activities were evaluated against the breast cancer cell line MD-AMB-231. The compound 3b exhibited the best anti-proliferative effect than trametenolic acid B and other derivatives with the IC50 of 17.78 µM.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

1135-1138

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1135

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Online since:

January 2013

Authors:

Ming Ruo Ding, Qiao Yin Zhang, Fang Hu, Nian Yu Huang, Jun Zhi Wang

Keywords:

Cytotoxic Activity, Structure Modification, Tetracyclic Triterpenoid, Trametenolic Acid B

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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