Design, Syntheses and Biological Evaluation of 5-Fluoroindolin-2-One Derivatives with Urea Linkage

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Abstract:

Nine 5-fluoroindolin-2-one derivatives with urea linkage were designed and synthesized. The obtained structures were identified by 1H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. Most of synthesized compounds showed antitumor activities, especially, compounds 6e and 6f, which were better than or equal to the antitumor activity of positive control.

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Advanced Materials Research (Volumes 634-638)

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926-929

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January 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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[1] Paul A. Renhowe, Sabina Pecchi, Cynthia M. Shafer, Timothy D. Machajewski: J. Med. Chem. Vol. 52 (2009), P. 278-292.

Google Scholar

[2] Arslan MA, Kutuk O, Basaga H: Curr Cancer Drug Targets. Vol. 6 (2006), P. 623.

Google Scholar

[3] Paul A. Renhowe, Sabina Pecchi, Cynthia M. Shafer, Timothy D: J. Med. Chem. Vol. 52 (2009), P. 278.

Google Scholar

[4] Mohammadi M, McMahon G, Sun L: Science. Vol. 276 (1997), P. 955.

Google Scholar

[5] Jianping Deng, Weiguo Zhao, Wantai Yang: Reactive & Functional Polymers. Vol. 67 (2007), P. 828.

Google Scholar

[6] Cai Xiong, Qian Changgeng, Gould Stephen, Zhai haixiao: WO2008033747.

Google Scholar