Rapid Biomimetic Deposition of Drug-Loaded Apatite Coatings

Lei Bao; Jing Xiao Liu; Fei Shi; Lian Peng Zhang; Yan Yan Jiang; Gui Shan Liu; Zhi Qiang Hu

doi:10.4028/www.scientific.net/AMR.712-715.439

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 712-715Rapid Biomimetic Deposition of Drug-Loaded Apatite...

Rapid Biomimetic Deposition of Drug-Loaded Apatite Coatings

Abstract:

In order to reduce the postoperative inflammation by the slow release of drugs at the beginning of implanting, drug-loaded apatite coatings and chitosan-apatite composite coatings on the NiTi alloy surface were prepared in the Simulated Body Fluid concentrated by five (5×SBF) under constant bubbling of carbon dioxide gas by biomimetic synthesis method. The composition and surface morphology of the coatings were studied using scanning electron microscopy (SEM) and X-ray diffraction (XRD). Additionally, a bacterial inhibition test was conducted for evaluating the drug slow release effects from the drug-loaded coatings. The results indicated that the porous apatite coatings with the flake structure could be deposited using the 5 times Simulated Body Fluid, and the drug-loaded chitosan-apatite composite coatings with better drug slow release effect were obtained. The incorporation of chitosan into the coatings could effectively control the drug release rate and was favorable for achieving better drug slow release effects.

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Periodical:

Advanced Materials Research (Volumes 712-715)

Pages:

439-442

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.712-715.439

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Online since:

June 2013

Authors:

Lei Bao, Jing Xiao Liu, Fei Shi, Lian Peng Zhang, Yan Yan Jiang, Gui Shan Liu, Zhi Qiang Hu

Keywords:

Apatite Coating, Biomimetic Synthesis, Chitosan, Drug-Loaded, NiTi Alloy

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