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Synthesis of the Novel Compounds 2-Lactosylthio-3-Alkyl/Alkoxythieno[3,2-d]Pyrimidin-4(3H)-Ones

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Abstract:

The title compounds 2-lactosylthio-3-alkyl/alkoxythieno [3,2-pyrimidin-4(3H)-ones 5 were synthesized after the alcoholysis reaction of protected 2-lactosylthio-3-alkyl/alkoxythieno [3,2-pyrimidin-4(3H)-ones 4 with the catalyst of ammonia water. The latters were synthesized from the materials ethyl 3-aminothiophene-2-carboxylate 1 and alkyl/arylisothiocyanates through the thiourea intermediaters 2 and heterocyclic compounds 3. Structural characterization of the target compounds were researched and their biological activity evaluation were underway in our laboratories.

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Periodical:

Advanced Materials Research (Volume 740)

Pages:

465-468

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.740.465

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Online since:

August 2013

Authors:

Qiu Hong Dai, Quan Bin Liao, Nian Yu Huang, Ming Guo Liu

Keywords:

Ethyl 3-Aminothiophene-2-Carboxylate, Lactose, Synthesis, Thieno[3,2-d]pyrimidin-4(3H)-One, Thiourea

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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