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Modified Octyl-2-Cyanoacrylate Tissue Adhesive for the Closure of Long Surgical Incisions

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Abstract:

Long surgical incisions required application of more flexible cyanoacrylate adhesive to relieve skin tension. A new formulation of octyl-2-cyanoacrylate (OCA) was modified by 0%, 3%, 6% and 9% (w/v) polytrimethylene carbonate (PTMC). The OCA/PTMC adhesives showed higher viscosity and bond strength than OCA monomer. The OCA/6% PTMC adhesive plus subcutaneous suture was used as group A (Treatment group), and the OCA/6% PTMC tissue adhesive alone was used as group B (Control group). 30 days later, there was no apparent scar formation in group A. A linear scar formation still could be seen in group B. The results supported the use of OCA/6% PTMC adhesive alone or adhesive plus subcutaneous suture in long surgical incisions, and the latter maintained better scar formation.

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Periodical:

Advanced Materials Research (Volumes 750-752)

Pages:

1597-1600

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.750-752.1597

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Online since:

August 2013

Authors:

Ming Wei Yuan, Yu Yue Qin, Ming Long Yuan, Hong Li Li

Keywords:

Biocompatibility, Bond Strength, Octyl-2-Cyanoacrylate, Polytrimethylene Carbonate, Tissue Adhesive

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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