Dynamic Self-Assembly Process of a Designed Peptide

Li Ping Ruan; Zhi Hua Xing

doi:10.4028/www.scientific.net/AMR.750-752.1630

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 750-752Dynamic Self-Assembly Process of a Designed...

Dynamic Self-Assembly Process of a Designed Peptide

Abstract:

In this paper, we reported the dynamic self-assembly process of an half-sequence ionic self-complementarity peptide CH₃CO-Pro-Ser-Phe-Cys-Phe-Lys-Phe-Glu-Pro-NH₂, which could self-assemble into stable nanofibers and formed hydrogel consisting of >99% water. The dynamic self-assembly process was detected by circular dichroism (CD) and atomic force microscopy (AFM). CD spectrum revealed that the mainly contents of the peptide were regular β-sheet structure. The data indicated that though the secondary structure of the peptide formed immediately, the microstructure of the self-assembly process of the designed peptide formed slowly. AFM image illustrated that the self-assembly process was layer-by-layer assembly.

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Periodical:

Advanced Materials Research (Volumes 750-752)

Pages:

1630-1634

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.750-752.1630

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Online since:

August 2013

Authors:

Li Ping Ruan*, Zhi Hua Xing

Keywords:

Atomic Force Microscopy (AFM), Circular Dichroism, Layer-By-Layer, Peptide, Self-Assembly

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