Study on Biochemical Materials with Development of Hollow and Paclitaxel-Loaded Bubbles for Ultrasound Controlled Drug Release

Shi Chao Wu; Xiang Rui Yang; Zhen Qing Hou; Qian Jiang; Yan Ge Wang

doi:10.4028/www.scientific.net/AMR.771.13

Paper Titles

Preparation and Characterization of Graphite Oxide
p.3

Electronic Structures in LaTiO₃/LaAlO₃ Multilayers
p.7

Study on Biochemical Materials with Development of Hollow and Paclitaxel-Loaded Bubbles for Ultrasound Controlled Drug Release
p.13

A Practical Judge Model to Simulate Lithium-Ion Battery Material Discharge Voltage Threshold
p.17

Effects of Rare Earth Metal Ce Additions on the 1150°C Isothermal Oxidation Behavior of Ni-20Cr Alloy
p.23

Experimental Investigation on the Influence of Water-Cement Ratio on Air-Void Parameters of Cement Concrete
p.29

Effect of Electrolytic/Chemical Pretreatment on Adhesion Strength of DLC Coatings on 304 Stainless Steel Substrate
p.35

Optimization of Ultrasonic Extraction Process by Response Surface Methodology of Polysaccharides from Tussilago farfara L.
p.41

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Study on Biochemical Materials with Development of Hollow and Paclitaxel-Loaded Bubbles for Ultrasound Controlled Drug Release

Abstract:

We report a new type of biochemical materialmultifunctional paclitaxel-loaded poly lactide-lecithin (PLA-lecithin) microbubbles which has been developed with a method of ultrasonic double emulsion solvent evaporation (UDES) combined with lyophilization. Bubbles were characterized to be hollow, well dispersed andwith size of 300nm~2um. Paclitaxel loading efficiency could reach up to 12%, and bubbles with different size and different lecithin content showed varied drug release characteristics but all displayed slow-release and ultrasound controlled properties, illustrating the ultrasound responsive drug release effect of the combination of microbubbles and ultrasound.

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Advanced Materials Research (Volume 771)

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13-16

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.771.13

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Online since:

September 2013

Authors:

Shi Chao Wu, Xiang Rui Yang, Zhen Qing Hou, Qian Jiang, Yan Ge Wang

Keywords:

Bubble, Drug Release, Lecithin-Polylactid (PLA), Paclitaxel, Ultrasound Contrast Agent

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