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The Resolusion of Ethyl (S)-Nipecotate and the New Synthesis of Ethyl-1- (2-Thiopheneacetyl)-3-Piperidine Carboxylate

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Abstract:

The optically pure ethyl nipecotate is an important drug intermediates. It was used for a variety of synthesis of APIs and pharmaceutical intermediates. In this paper we launched a study of the split of ethyl nipecotate. An efficient resolution of (±)-nipecotic acid has been achieved by the fractional crystallization with good yield and high enatio. The compound (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidine-carboxylate is an investigational immune potentiating agent targeting direct stimulation of immune cells, useful for the prevention of infectious diseases in livestock.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

198-201

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.198

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Online since:

September 2013

Authors:

Xiao Xia Sun, Ying Chun Li, Xiao Xiao Zhuang, Yu Hu

Keywords:

(S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, Resolution, R-Nipecotic Acid

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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