Ultrasound Promoted Synthesis and Antibacterial Activity of 5-Aryl-l,3,4-oxadiazole-2-yl Sulfanyl Derivatives

Ying Jie Lei; Xin Shi Wu; Mei Ding

doi:10.4028/www.scientific.net/AMR.815.803

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 815Ultrasound Promoted Synthesis and Antibacterial...

Ultrasound Promoted Synthesis and Antibacterial Activity of 5-Aryl-l,3,4-oxadiazole-2-yl Sulfanyl Derivatives

Abstract:

In order to search for new bioactive substances containing 1,3,4-oxadiazole, some 5-aryl-l,3,4-oxadiazole-2-ylsulfanyl derivatives were synthesized from the active intermediate 5-aryl-l,3,4-oxadiazole-2-thiones, obtained from the condensation of aromatic carboxylic acid hydrazides and carbon disulfide at triethylamine alkaline solution catalyzed by propylphosphonic anhydride, followed by reaction with ethyl chloroacetate in alkaline media under ultrasound irradiation in the presence of PEG-400. The structural features were confirmed by IR, 1HNMR spectra and elemental analysis. These compounds have been screened for their good antibacterial activities against Escherichia coli, Staphyhcoccus aureus and Bacillus Subtilis.

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Progress in Materials Science and Engineering: ICMSE 2013

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Advanced Materials Research (Volume 815)

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803-806

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https://doi.org/10.4028/www.scientific.net/AMR.815.803

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October 2013

Authors:

Ying Jie Lei, Xin Shi Wu, Mei Ding

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1,3,4-Oxadiazoles, Antibacterial Activity, Sulfanyl, Ultrasound irradiation

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