Natural Rubber Latex Foam Loading with Metronidazole

Abstract:

Normally, natural rubber latex foam (NRLF) has been produced from natural rubber latex with centrifugation and addition of foaming agent such as ammonium olaete. In this study, the different porosities of NRLFs were loaded with metronidazole (MET), the antibiotic and powerful antiprotozoal agent. NRLFs topography, water uptake and erosion properties were studied. Release of MET from NRLFs was performed in phosphate buffer pH 7.4 at 37°C and the cumulative amount of MET liberation was determined by UV-Vis spectrophotometer. NRLFs exhibited the apparent porous structure with highly water uptake and no erosion. Burst release of MET from NRLFs was noticed for all NRLFs. Therefore, the MET-loaded NRLFs were properly suitable for fast release and their dramatically porous topography was applicable for high loading capacity of selected active compounds.

• Periodical: Advanced Materials Research (Volume 844)
• Pages: 490-493
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.844.490
• Online since: November 2013
• Authors: Pongsathorn Issarayungyuen, Nattapong Nithi-Uthai, Wiwat Pichayakorn, Thawatchai Phaechamud*
• Keywords: Foam, Metronidazole, Natural Rubber (NR)

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