Synthesis and Properties of Molecularly Imprinted Composite Membranes of Roxithromycin
Molecularly imprinted composite membranes for selective binding and permeation of roxithromycin were prepared by means of thermal initiated co-polymerization method using polysulfone ultra-filtration membranes as porous supports. Scanning electron microscope was utilized to visualize surface and cross-sections of the membranes to gain more better understanding in the analysis of imprinted layers deposited on PSF support membranes and differential scanning calorimetric was used for determining the thermal stability of the membranes. Static equilibrium binding and recognition properties of the imprinted and non-imprinted membranes to roxithromycin and its analogues in ethanol solution system were tested. The results showed that saturated binding capacity of imprinted membrane to roxithromycin was about 2.24μmol/g, higher than those of its analogues, and the selectivity factors of αRM/EM, αRM/AM and αRM/EE were 1.75, 2.46 and 2.67, respectively. The transport performances of the membranes were evaluated through kinetic filtration experiments. The separation mechanism of the roxithromycin imprinted membrane could be defined as facilitated permeation mechanism.
Lianxiang Ma, Chuangsheng Wang and Weimin Yang
J. Y. Yu et al., "Synthesis and Properties of Molecularly Imprinted Composite Membranes of Roxithromycin", Advanced Materials Research, Vols. 87-88, pp. 80-85, 2010