Preparation and Characterization of Nanostructured Lipid Carriers Loaded Spirogyra spp. Extract

Abstract:

Many compounds with high lipophilic character incorporated into nanostructured lipid carriers (NLC) have been reported. However, hydrophilic compounds have not been completely investigated. In this paper, we investigated the potential of lipid nanoparticles as carriers for aqueous extract of Spirogyra spp. using hot high-pressure homogenization method. The aqueous extract of Spirogyra spp. (AS-NLC) showed spherical morphology with smooth surface under transmission electron microscope (TEM). The encapsulation efficiency was 61.23±6.25%. The crystallization of AS in NLC was investigated by X-ray diffraction. AS was in an amorphous state in the NLC matrix. The in vitro release experiments of NLC exhibited biphasic release pattern with burst release at the initial 3 h and prolonged release afterwards.

• Periodical: Advanced Materials Research (Volume 894)
• Pages: 323-327
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.894.323
• Online since: February 2014
• Authors: Thitiphan Chimsook
• Keywords: Encapsulation, Nanostructured Lipid Carriers, Spirogyra spp.

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