Controlled Release of Hydrophilic Guest Molecules from Photoresponsive Nucleolipid Vesicles

Abstract:

We here report a novel design and synthesis of a light-responsive nucleolipid by introducing an o-nitrobenzyl group that acts as a linker between a nucleotide and a lipid. The nucleolipid was applied readily to preparing smart vesicles and encapsulating hydrophilic guest molecules 5(6)-carboxyfluorescein (CF) in their inner aqueous phase. Upon light irradiation, their vesicular structure was disrupted as a result of the photolytic degradation of the nucleotide, resulting in CF release. Furthermore, temporally controlled CF release from these vesicles could be readily realized by turning on and off light. By demonstrating the molecular assembly and photo-disassembly cycle, this report aims to stimulate further research exploring practical applications of nucleolipids.

• Periodical: Advanced Materials Research (Volumes 912-914)
• Pages: 519-522
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.912-914.519
• Online since: April 2014
• Authors: Ya Wei Sun*
• Keywords: Controlled Release, Nucleolipid, Photolabile, Vesicles

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