Biological Activity Studies on a Copper(II) Complex with Taurine Schiff Base

Mei Li; Guo Ping Yang; Hong Liang

doi:10.4028/www.scientific.net/AMR.912-914.57

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 912-914Biological Activity Studies on a Copper(II)...

Biological Activity Studies on a Copper(II) Complex with Taurine Schiff Base

Abstract:

A new material of copper(II) complex (complex 1) with taurine Schiff base has been synthesized and characterized by elemental analysis, ESI-MS and IR spectra. 1 was tested against HepG2 cell lines with IC50 values of 12.89 μM. With the concentrations of 1 increasing, the population of apoptosis was 1.28% for 0 μM, 24.4% for 10 μM and 47.9% for 20μM, and the population of G2 phase was 19.2% for 0 μM, 34.4% for 10 μM and 42.9% for 20μM, respectively. 1 showed significant cytotoxic activity against HepG2 cell lines.

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Periodical:

Advanced Materials Research (Volumes 912-914)

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57-60

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.912-914.57

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Online since:

April 2014

Authors:

Mei Li*, Guo Ping Yang, Hong Liang

Keywords:

Copper Complex, Cytotoxic Activity, HepG2 Cell Lines, Taurine Schiff Base

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