Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications
New hybrid macroporous scaffolds of polycaprolactone (PCL)/tricalcium phosphate (TCP) were developed by taking into account mechanical properties of the bone to be replaced. FTIR spectra indicated the coating of TCP onto the polymer, providing hydrophilic surfaces necessary for cells to attach. As determined by DSC, the depression of PCL melting point suggested a uniform distribution of PCL within the TCP matrix. SEM micrographs revealed pores of irregular shapes varying from 100-200 µm in size in the resultant structures. Indeed, the pore morphology was precisely determined by the leached particles. The scaffolds could tolerate the impact of at least 5.6 kNm2, making them suitable for use as artificial bones of skull, clavicle and ribs. Rat bone stroma attached and survived on the scaffolds, indicating biocompatible of the used materials. Therefore, the prepared scaffolds would be applicable for bone tissue engineering in the near future.
S. Suttiruengwong and W. Sricharussin
L. Kaewsichan et al., "Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications", Advanced Materials Research, Vols. 93-94, pp. 67-70, 2010