Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications

Lupong Kaewsichan; Jasadee Kaewsrichan; Thitima Chuchom

doi:10.4028/www.scientific.net/AMR.93-94.67

Paper Titles

Design Net-Grid Subwavelength Gratings for High Quantum Efficiency Photodetectors
p.43

Polarization Switching Behavior of Ferroelectric (NH₄)_0.39K_0.61NO₃ Films
p.49

Performance of Bioactive Hydroxyapatite Coating after Soaking in Simulated Body Fluid
p.59

Effect of Layer Thickness on the Phosphorization of 3DP Gypsum Based Monolith
p.63

Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications
p.67

Gamma-Rays Absorption Studies of PbO-SiO₂ Glass System
p.71

Influences of Water on the Hydration of Calcined Natural Calcite: Properties and Transesterification Activity Improvement
p.75

Nd:YAG Laser Perforation of Plastic Films for Enhanced Breathability
p.79

Preparation of Nanoparticles by Laser Ablation on Copper Target in Distilled Water
p.83

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 93-94Nanostructured Polycaprolactone-Inorganic...

Nanostructured Polycaprolactone-Inorganic Phosphate Hybrid Scaffold for Medical Applications

Abstract:

New hybrid macroporous scaffolds of polycaprolactone (PCL)/tricalcium phosphate (TCP) were developed by taking into account mechanical properties of the bone to be replaced. FTIR spectra indicated the coating of TCP onto the polymer, providing hydrophilic surfaces necessary for cells to attach. As determined by DSC, the depression of PCL melting point suggested a uniform distribution of PCL within the TCP matrix. SEM micrographs revealed pores of irregular shapes varying from 100-200 µm in size in the resultant structures. Indeed, the pore morphology was precisely determined by the leached particles. The scaffolds could tolerate the impact of at least 5.6 kNm2, making them suitable for use as artificial bones of skull, clavicle and ribs. Rat bone stroma attached and survived on the scaffolds, indicating biocompatible of the used materials. Therefore, the prepared scaffolds would be applicable for bone tissue engineering in the near future.