Preparation and Evaluation of Calcium Alginate/Glycyrrhizic Acid Hydrogel

Ying Zong Ren; Yi Zhang; Li Na Gao; Yuan Lu Cui; Yun Qi

doi:10.4028/www.scientific.net/AMR.941-944.1065

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 941-944Preparation and Evaluation of Calcium...

Preparation and Evaluation of Calcium Alginate/Glycyrrhizic Acid Hydrogel

Abstract:

Calcium ions released from calcium-alginate hydrogel can promote inflammatory responses when injected subcutaneously in mice. In this study, a novel alginate hybrid hydrogel was prepared using sodium alginate (SA) and Glycyrrhizic acid (GA) design for reduce calcium concentration in the hydrogel. nanoCalcium carbonate was wrapped in an alginate solution and internal gelling was induced by the Ca²⁺ released from CaCO₃ by adding of GA. As varying of the amounts of GA and CaCO₃ in alginate solution, the gelling time could be controlled within 10 min. Taking advantage of short gelation time and controlled hydrogel shape, GA calcium alginate hydrogel system has great potential for tissue engineering applications.

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Periodical:

Advanced Materials Research (Volumes 941-944)

Pages:

1065-1068

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.941-944.1065

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Online since:

June 2014

Authors:

Ying Zong Ren, Yi Zhang, Li Na Gao, Yuan Lu Cui*, Yun Qi

Keywords:

Calcium Ion, Gelation Time, Glycyrrhizic Acid, Hydrogel, Sodium Alginate

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