Hyaluronic Acid Production by Genetic Modified GRAS Strains

Abstract:

Hyaluronic acid is an important polysaccharide of various physiological functions. Nowadays, it is produced mainly through microbial fermentation of Streptococcus zooepidemicus. HA production in more safe and efficient genetic modified GRAS strains is a hot research area. Bacillus subtilis, Lactococcus lactis, Streptococcus thermophiles, Agrobacterium sp. , and some Escherichia coli strains, which were GRAS strains, had been selected for genetic engineering to express hyaluronic acid. Here, we provide a comprehensive review of HA production by these genetic modified GRAS strains.

• Periodical: Advanced Materials Research (Volume 950)
• Pages: 13-17
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.950.13
• Online since: June 2014
• Authors: Xiao Fang*, Rong Shuai Duan, Hai Ying Yang, Jing Feng Liu
• Keywords: GRAS, Hyaluronansynthase, Hyaluronic Acid

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