Triphosgene as a Safe and Environment-Friendly Carbonylation Reagent for the Preparation of 2-Benzimidazolone

Abstract:

2-Benzimidazolone and their derivatives which have a wide range of biological and pharmaceutical activity are important intermediates for organic synthesis. Reported synthetic methods mostly involved unfriendly materials like phosgene, dimethyl carbonate and urea. This paper developed a novel method for the synthesis of 2-benzimidazolone by the reaction of o-phenylendiamine with triphosgene (BTC) instead of phosgene. BTC is a safer solid and easier to handle compared to phosgene. BTC can greatly reduce risks to both human health and the environment.

• Periodical: Advanced Materials Research (Volumes 955-959)
• Pages: 651-655
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.955-959.651
• Online since: June 2014
• Authors: Wen Bin Yi*, Fang Luan, Jian Min Xiu, Lv Qi Jiang, Chun Cai
• Keywords: 2-benzimidazolone, Green Chemistry, O-Phenylendiamine, Phosgene, Triphosgene

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