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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 955-959Application of the MCF-7 Breast Cancer Cells in...

Application of the MCF-7 Breast Cancer Cells in Endocrine-Disrupting Area

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Abstract:

MCF-7 breast cancer cell line was first developed by Dr. Herbert Soule from a pleural effusion taken from a patient with metastatic breast cancer. This estrogen-responsive and estrogen receptor containing cell line can also express androgen, progesterone, glucocorticoid and retinoid receptors. It has been extensively used in identifying environmental estrogens and exploring the toxicity mechanisms, as well as the pathologic study and the disease treatment. This mini review article will focus on the development and application of MCF-7 cells in endocrine-disrupting area, especially in study of environmental estrogens.

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Advances in Environmental Technologies III

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Periodical:

Advanced Materials Research (Volumes 955-959)

Pages:

928-935

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.955-959.928

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Online since:

June 2014

Authors:

Ling Ying Zhong, Xiao Xiang, Jing Ye, Wei Lu, Jing Lv, Dong Wei Zhang, Bing Xia, Pei Zhou, Lu Mei Wang*

Keywords:

Breast Cancer Cell, Endocrine Disrupting Chemicals, MCF-7

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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